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In deciphering the global signaling capacity of FERONIA receptor kinase, Liu, Yeh, et al. discovered an extracellular phase separation process driven by FERONIA peptide ligand RALF-cell wall polysaccharide pectin interaction, which leads to cognate and non-cognate receptor clustering and promiscuous endocytosis as a coping mechanism in response to environmental stressors. Highlights Cell surface pectin-RALF1 phase separation recruits FERONIA-LLG1 into condensates RALF induces FERONIA-LLG1-dependent promiscuous receptor clustering and endocytosis RALF1-pectin molecular condensates function as surface sensors for stress signals FERONIA-LLG1-mediated global endocytosis ensures plant resilience under stressmore » « less
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Duan, Qiaohong; Liu, Ming-Che James; Kita, Daniel; Jordan, Samuel S.; Yeh, Fang-Ling Jessica; Yvon, Robert; Carpenter, Hunter; Federico, Anthony N.; Garcia-Valencia, Liliana E.; Eyles, Stephen J.; et al (, Nature)
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